Introduction
My name is Toshiya HIBINO. My blood type is B.
I am 22 years old and graduate student in Fukui University.
My home town is Nagoya city in Aichi. Nagoya is so big city and so many people lived in there. The picture is view of Nagoya city from Nagoya castle. In spring, we go to there and have a picnic under a cherry blossom tree.
My hobby is cycling, Japanese archery and watching movie. I went to Shikoku by cycling for 1 week. In holiday, I go to some place in Fukui. Cycling is recommended as you can sightseeing as well as exercise.
About Japanese archery, I started Japanese archery in high school. Japanese archery is traditional and cool sports. I enjoyed it with old people. It is recommended sports because age does not matter. So, please challenge!
I often watch movie in my house. My favorite movie types are documentaries and human dramas. The picture is my favorite movie. This movie is not only interesting content, easy to understand English. The reason First of all, the reason why I started watching movies was to study English. This movie is highly recommended for those who watch movies for the first time.
I am 22 years old and graduate student in Fukui University.
My home town is Nagoya city in Aichi. Nagoya is so big city and so many people lived in there. The picture is view of Nagoya city from Nagoya castle. In spring, we go to there and have a picnic under a cherry blossom tree.
My hobby is cycling, Japanese archery and watching movie. I went to Shikoku by cycling for 1 week. In holiday, I go to some place in Fukui. Cycling is recommended as you can sightseeing as well as exercise.
About Japanese archery, I started Japanese archery in high school. Japanese archery is traditional and cool sports. I enjoyed it with old people. It is recommended sports because age does not matter. So, please challenge!
I often watch movie in my house. My favorite movie types are documentaries and human dramas. The picture is my favorite movie. This movie is not only interesting content, easy to understand English. The reason First of all, the reason why I started watching movies was to study English. This movie is highly recommended for those who watch movies for the first time.
My research
Title : Fabrication and estimation of PLLA/Collagen coaxial nanofiber for controlled drug release
Current methods of administering medication have many problems. So many drug delivery systems were developed. Most popular administration is oral or inject. But they has problem. It is that can not supply drug directly to the affected area for medium to long term. In other words, the efficiency of the drug is very bad. Therefore, we need to drink medication frequently. Side effects also occur. So we have to fabricate new drug delivery system that can supply drug directly to the affected area for medium to long term.
I focused on fiber materials. Fiber materials are attracting attention as bio material and many researches are being conducted. Especially, nano fiber is expected as a carrier material for drug delivery system because of its high process ability and easy to fabricate by electroplating. Electrosoinnning is famous method to fabricate nano fiber using electrostatic interaction. We can give biodegradability and biodegradability to nano fiber using bio material to material of nano fiber. However, it is difficult to control drug release by using nano fiber fabricated with conventional electrospinning method due to burst release of the incorporated drug in the early stage, because of nano fiber has high surface area.
To issue the problem about nano fiber, in this study, we fabricate core-shell nano fiber by electrospinning. It is called co-axial nano fiber because the structure of co-axial nano fiber is such like pencil. It has core of drug-loaded collagen and shell of poly L-lactic acid (PLLA) for inhibiting the diffusion of the drug release. Collagen and PLLA is popular material because it is totally decomposed in vivo and harmless. I fabricated co-axial nano fiber and analyzed behavior of drug release from core-shell nano fiber and crystal structure.
In the future, this drug delivery system will be used for anticancer therapy after surgery. The first, the surgeon remove cancer from the body. After removing, they stick it to the treatment site in the body. The drug delivery system will supply anticancer drug to treatment site to treat residual cancer cells. I hope this drug delivery system will be used in popular and help so many patient.
I focused on fiber materials. Fiber materials are attracting attention as bio material and many researches are being conducted. Especially, nano fiber is expected as a carrier material for drug delivery system because of its high process ability and easy to fabricate by electroplating. Electrosoinnning is famous method to fabricate nano fiber using electrostatic interaction. We can give biodegradability and biodegradability to nano fiber using bio material to material of nano fiber. However, it is difficult to control drug release by using nano fiber fabricated with conventional electrospinning method due to burst release of the incorporated drug in the early stage, because of nano fiber has high surface area.
To issue the problem about nano fiber, in this study, we fabricate core-shell nano fiber by electrospinning. It is called co-axial nano fiber because the structure of co-axial nano fiber is such like pencil. It has core of drug-loaded collagen and shell of poly L-lactic acid (PLLA) for inhibiting the diffusion of the drug release. Collagen and PLLA is popular material because it is totally decomposed in vivo and harmless. I fabricated co-axial nano fiber and analyzed behavior of drug release from core-shell nano fiber and crystal structure.
In the future, this drug delivery system will be used for anticancer therapy after surgery. The first, the surgeon remove cancer from the body. After removing, they stick it to the treatment site in the body. The drug delivery system will supply anticancer drug to treatment site to treat residual cancer cells. I hope this drug delivery system will be used in popular and help so many patient.